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The effects of exercise training on sympathetic neural activation in advanced heart failure

A randomized controlled trial

Fabiana Roveda, MD, PhD^*, Holly R. Middlekauff, MD, Maria Urbana P. B. Rondon, PhD^*, Soraya F. Reis, BS^*, Márcio Souza, MS, Luciano Nastari, MD^*, Antonio Carlos P. Barretto, MD, PhD^*, Eduardo M. Krieger, MD, PhD^* and Carlos Eduardo Negrão, PhD^*,*

^* Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil
University of California, Los Angeles, Medical School, Department of Cardiology, Los Angeles, California, USA
School of Physical Education and Sports, University of São Paulo, São Paulo, Brazil

View larger version (39K): [in a new window]   Figure 1 Sympathetic neurograms. (A) Heart failure patients, exercise group. Pre-training, muscle sympathetic nerve activity (MSNA) is markedly elevated. Post-exercise training, sympathetic nerve activity levels are reduced. (B) Heart failure patients, sedentary group; MSNA levels are markedly elevated before and after the sedentary period.

View larger version (27K): [in a new window]   Figure 2 Muscle sympathetic nerve activity (MSNA) pre/post exercise/sedentary periods quantified as bursts/min (A) and bursts/100 heart beats (B). Post-exercise training MSNA levels compared with pre-training MSNA levels in heart failure (HF) patients are uniformly and markedly reduced and are no longer higher than normal controls; MSNA remained unchanged in the HF sedentary group and the normal control exercise group.