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Coronary vasoregulation in patients with various risk factors in response to cold pressor testing

Contrasting myocardial blood flow responses to short- and long-term vitamin C administration

Thomas H. Schindler, MD^*,*, Egbert U. Nitzsche, MD^*, Thomas Munzel, MD, Manfred Olschewski, MSc, Ingo Brink, MD^*, Michael Jeserich, MD^*, Michael Mix, MSc^*, Peter T. Buser, MD, FACC, FESC, Matthias Pfisterer, MD, FACC, FESC, Ulrich Solzbach, MD^* and Hanjörg Just, MD, FRCP, FESC, FAHA^*

^* Division of Cardiology and Nuclear Medicine, Medical Clinic III, University Hospital of the Albert Ludwig University, Freiburg, Germany
Division of Cardiology and Nuclear Medicine, University Hospital, Basel, Switzerland
Division of Cardiology, Medical Clinic III, University Hospital Eppendorf Hamburg, Hamburg, Germany
Institute for Medical Statistics and Biometry, Albert Ludwigs University, Freiburg, Germany

View larger version (11K): [in a new window]   Figure 1 Study protocol. CPT = cold pressor test; MBF = myocardial blood flow; PET = positron emission tomography; VC = vitamin C.

View larger version (18K): [in a new window]   Figure 2 Percent change of myocardial blood flow (MBF) during cold pressor testing (CPT) in hypercholesterolemic patients (open bars), hypertensive patients (solid bars), and smokers (lined bars). #+p 0.03 compared with baseline (CPT-1) on repeated assessments for each study group.

View larger version (17K): [in a new window]   Figure 3 Changes of myocardial blood flow (MBF) during cold pressor testing (CPT) at baseline (CPT-1), after intravenous (i.v.) infusion of 3 g vitamin C (VC) (CPT-2), and after a period of three months (CPT-3) and two years (CPT-4) of 2 g VC tablets daily in smokers. #+¡p 0.001 compared with baseline (CPT-1) on repeated assessments of changes in MBF during CPT in smokers.