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Glucose-insulin-potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction

The glucose-insulin-potassium study: a randomized trial

Iwan C. C. van der Horst, MD^*, Felix Zijlstra, MD, PhD, FACC^,*, Arnoud W. J. van't Hof, MD, PhD^*, Carine J. M. Doggen, MSc, PhD^||, Menko-Jan de Boer, MD, PhD^*, Harry Suryapranata, MD, PhD, FACC^*, Jan C. A. Hoorntje, MD, PhD^*, Jan-Henk E. Dambrink, MD, PhD^*, Rijk O. B. Gans, MD, PhD, Henk J. G. Bilo, MD, PhD Zwolle Infarct Study Group

^* Department of Cardiology, Isala Klinieken, Hospital de Weezenlanden, Zwolle, The Netherlands
Department of Internal Medicine, Isala Klinieken, Hospital de Weezenlanden, Zwolle, The Netherlands
Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands
Department of Internal Medicine, University Hospital Groningen, Groningen, The Netherlands
^|| Department of Clinical Epidemiology, University Medical Center, Leiden, The Netherlands

View larger version (11K): [in a new window]   Figure 1 Kaplan-Meier curve showing cumulative survival of patients randomized to glucose-insulin-potassium (GIK) group or control group. Differences between the groups were nonsignificant (unadjusted p = 0.50). The p value was determined with the use of the log-rank test. Solid line = GIK group; dotted line = control group.

View larger version (11K): [in a new window]   Figure 2 Kaplan-Meier curve showing cumulative survival of Killip 1 class patients randomized to glucose-insulin-potassium (GIK) group or control group. Differences between the groups were significant (unadjusted p = 0.01). P value was determined with the use of the log-rank test. Solid line = GIK group; dotted line = control group.

View larger version (27K): [in a new window]   Figure 3 Relative risk (dots) and 95% confidence intervals (lines) of glucose-insulin-potassium (GIK) on 30-day mortality in overall population and in predefined subgroups. MI = myocardial infarction; TIMI = Thrombolysis In Myocardial Infarction.