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J Am Coll Cardiol, 2003; 42:765-770, doi:10.1016/S0735-1097(03)00779-4
© 2003 by the American College of Cardiology Foundation
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Treatment of fetal tachycardia with sotalol: transplacental pharmacokinetics and pharmacodynamics

Martijn A. Oudijk, MD, PhD*,*, Jopje M. Ruskamp, MD{dagger}, F. F. Tessa Ververs, PharmD{ddagger}, E. Barbara Ambachtsheer, MD{dagger}, Philip Stoutenbeek, MD, PhD*, Gerard H. A. Visser, MD, PhD* and Erik J. Meijboom, MD, PhD, FACC§

* Department of Obstetrics, Utrecht, The Netherlands
{dagger} Division of Pediatric Cardiology, Utrecht, The Netherlands
{ddagger} Division of Hospital Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands
§ Division of Pediatric Cardiology, Central Hospital University of Vaud, Lausanne, Switzerland



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Figure 1 Details on diagnosis, treatment modalities, and outcome of all cases. SVT = supraventricular tachycardia; AF = atrial flutter; SC = Caesarean section.

 


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Figure 2 Mean interquartile range and overall range of maternal blood levels of sotalol per daily dosage. Number of women with observations is shown within brackets. A linear relationship between blood level and increasing dosage is shown.

 


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Figure 3 Mean interquartile range and overall range of umbilical blood level of sotalol per daily maternal dosage. Number of observations is shown within brackets.

 




 
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