Treatment of fetal tachycardia with sotalol: transplacental pharmacokinetics and pharmacodynamics
Martijn A. Oudijk, MD, PhD*,*,
Jopje M. Ruskamp, MD ,
F. F. Tessa Ververs, PharmD ,
E. Barbara Ambachtsheer, MD ,
Philip Stoutenbeek, MD, PhD*,
Gerard H. A. Visser, MD, PhD* and
Erik J. Meijboom, MD, PhD, FACC
* Department of Obstetrics, Utrecht, The Netherlands
Division of Pediatric Cardiology, Utrecht, The Netherlands
Division of Hospital Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Cardiology, Central Hospital University of Vaud, Lausanne, Switzerland

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Figure 1 Details on diagnosis, treatment modalities, and outcome of all cases. SVT = supraventricular tachycardia; AF = atrial flutter; SC = Caesarean section.
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Figure 2 Mean interquartile range and overall range of maternal blood levels of sotalol per daily dosage. Number of women with observations is shown within brackets. A linear relationship between blood level and increasing dosage is shown.
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Figure 3 Mean interquartile range and overall range of umbilical blood level of sotalol per daily maternal dosage. Number of observations is shown within brackets.
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