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Long-term statin use and psychological well-being

Yinong Young-Xu, MS, MA^*,*, K. Arnold Chan, MD, James K. Liao, MD, FACC, Shmuel Ravid, MD, FACC^* and Charles M. Blatt, MD, FACC^*

^* Lown Cardiovascular Research Foundation, Brookline, Massachusetts, USA
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Department of Medicine, Brigham and Women's Hospital, Boston, MassachusettsUSA
Department of Nutrition, Harvard School of Public Health, Boston, MassachusettsUSA

View larger version (20K): [in a new window]   Figure 1 Association between change in Kellner Symptom Questionnaire score and consecutive years of statin use or no use of cholesterol-lowering drugs.

View larger version (18K): [in a new window]   Figure 2 Odds ratios of abnormal psychometric scores and length of consecutive statin usage. *The generalized estimating equations longitudinal multivariate model with adjustment for propensity, as well as age (age minus mean age); length of follow-up; gender; education (below vs. above college education); blood glucose level; systolic and diastolic blood pressure; total cholesterol; high density lipoprotein level; heart rate; current smoking; regular exercise; alcohol use; past major life events; anticipated major future life events; use of antidepressants and anti-anxiety drugs at time of enrollment; statin use prior to study entry; use of beta blockers or calcium channel blockers at enrollment and during follow-up; history of catheterization, myocardial infarction, hypertension, and diabetes; incidence of myocardial infarction, stroke, catheterization, and revascularization.