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Long-term treatment with Low-Dose, but not High-Dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction

^* Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan

View larger version (43K): [in a new window]   Figure 1 Echocardiographic variables of sham-operated rats (SH) (n = 6), SH rats treated with high-dose guanethidine (SH+HG) (n = 7), rats with myocardial infarction receiving vehicle (MI) (n = 12), and MI rats treated with low-dose guanethidine (MI+LG) (n = 13), medium-dose guanethidine (MI+MG) (n = 8), and high-dose guanethidine (MI+HG) (n = 3). *p < 0.05 vs. sham-operated rats. p < 0.05 vs. MI rats. p < 0.05 vs. MI+LG rats. The difference between MI+HG rats and the other groups was not compared because of the small number. Data are presented as the mean value ± SD. FS = fractional shortening of left ventricle; LVEDD and LVESD = left ventricular end-diastolic and end-systolic dimension, respectively.

View larger version (22K): [in a new window]   Figure 2 Plasma norepinephrine (NE) concentrations (left panel) and NE contents of noninfarcted left ventricle (right panel) of sham-operated rats (SH) (n = 6), SH rats treated with high-dose guanethidine (SH+HG) (n = 7), rats with myocardial infarction receiving vehicle (MI) ( n = 12), and MI rats treated with low-dose guanethidine (MI+LG) (n = 13), medium-dose guanethidine (MI+MG) (n = 8), and high-dose guanethidine (MI+HG) (n = 3). The plasma NE concentration of MI+HG rats was not measured. *p < 0.05 vs. sham-operated rats. p < 0.05 vs. MI rats. p < 0.05 vs. MI+LG rats. The difference between MI+HG rats and the other groups was not compared because of the small number. Data are presented as the mean value ± SD.

View larger version (16K): [in a new window]   Figure 3 Kaplan-Meier survival curves of sham-operated rats treated with high-dose guanethidine (SH+HG) (n = 7), rats with myocardial infarction receiving vehicle (MI) (n = 25), and MI rats treated with low-dose guanethidine (MI+LG) (n = 17), medium-dose guanethidine (MI+MG) (n = 20), and high-dose guanethidine (MI+HG) (n = 34). Survival of sham-operated rats receiving vehicle (100%) is not shown. *p < 0.05 vs. MI rats. p <0.05 vs. MI+MG rats.

View larger version (21K): [in a new window]   Figure 4 The 24-h and 28-day mortality of rats with myocardial infarction receiving vehicle (MI) (n = 25) and MI rats treated with low-dose guanethidine (MI+LG) (n = 17), medium-dose guanethidine (MI+MG) (n = 20), and high-dose guanethidine (MI+HG) (n = 34). *p < 0.05 vs. MI rats. p < 0.05 vs. MI+LG rats. p < 0.05 vs. MI+MG rats.