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Plasma C-reactive protein as a marker of cardiac allograft vasculopathy in heart transplant recipients

Aina Hognestad, MD^*,*, Knut Endresen, MD, PhD^*, Ragnhild Wergeland, MS, Oddvar Stokke, MD, PhD, Odd Geiran, MD, PhD, Torbjorn Holm, MD, PhD^*, Svein Simonsen, MD, PhD^*, John K. Kjekshus, MD, PhD^* and Arne K. Andreassen, MD, PhD^*

^* Department of Cardiology, Rikshospitalet, Oslo, Norway
Department of Clinical Chemistry, Rikshospitalet, Oslo, Norway
Department of Thoracic Surgery, Rikshospitalet, Oslo, Norway

View larger version (13K): [in a new window]   Figure 1 Levels of high-sensitivity C-reactive protein (hsCRP) among patients with normal angiograms (squares) and patients with angiographic evidence of cardiac allograft vasculopathy (CAV) (triangles). The horizontal line indicates the median of the hsCRP values.

View larger version (29K): [in a new window]   Figure 2 Numbers of patients with normal angiograms (lined bars) and with angiographic evidence of cardiac allograft vasculopathy (solid bars) in each quartile of high-sensitivity C-reactive protein levels. The odds ratio between the first and fourth quartile is 24.75 (95% confidence interval 6.86 to 89.31).

View larger version (14K): [in a new window]   Figure 3 The receiver operating characteristics (ROC) curve of high-sensitivity C-reactive protein as a marker for cardiac allograft vasculopathy. The ROC area was 0.80 (95% confidence interval 0.72 to 0.87; p < 0.001).

View larger version (15K): [in a new window]   Figure 4 Median levels of high-sensitivity C-reactive protein (hsCRP) by severity of cardiac allograft vasculopathy (CAV).

View larger version (9K): [in a new window]   Figure 5 Delta values (expressed as mean values) of high-sensitivity C-reactive protein (hsCRP) from baseline to follow-up among patients with normal angiograms (cardiac allograft vasculopathy [CAV]–) and in patients with angiographic evidence of CAV (CAV+).