This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Diamant, M. Articles by Radder, J. K. Search for Related Content PubMed PubMed Citation Articles by Diamant, M. Articles by Radder, J. K.

Diastolic dysfunction is associatedwith altered myocardial metabolism inasymptomatic normotensive patientswith well-controlled type 2 diabetes mellitus

Michaela Diamant, MD, PhD^*||,*, Hildo J. Lamb, PhD, Ymte Groeneveld, MD, PhD, Edwin L. Endert, Jan W. A. Smit, MD, PhD^*, Jeroen J. Bax, MD, PhD, Johannes A. Romijn, MD, PhD^*, Albert de Roos, MD, PhD and Jasper K. Radder, MD, PhD^*

^* Departments of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Radiology, Leiden University Medical Center, Leiden, The Netherlands
General Practice, Leiden University Medical Center, Leiden, The Netherlands
Cardiology, Leiden University Medical Center, Leiden, The Netherlands
^|| Department of Endocrinology/Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands

View larger version (17K): [in a new window]   Figure 1 (A) Mean ± SD myocardial phosphocreatine to adenosine-triphosphate (PCr/ATP) ratios in type 2 diabetic patients (solid bar) and controls (open bar). *p < 0.01. (B) Representative phosphorus-31 magnetic resonance spectroscopy (31P-MRS) obtained at rest from the anterior left ventricular wall of a patient (upper panel) and healthy subject (lower panel). The peaks of PCr, ATP, and inorganic phosphate (Pi) plus 2,3-diphospho-glycerate (2,3-DPG) are identified in the upper panel. Myocardial PCr/ATP ratios, as presented below the 31P-MRS, were corrected for partial saturation effects and blood-ATP contamination, and line broadening of 15 Hz was applied.

View larger version (14K): [in a new window]   Figure 2 The association between myocardial phosphocreatine/adenosine-triphosphate (PCr/ATP) and E peak filling rate (A) and E acceleration peak (B), representing indexes of diastolic function, in type 2 diabetic patients (solid dots) and healthy controls (open dots). See also Table 3 and text.