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Ultrasound tissue characterization detectspreclinical myocardial structural changes inchildren affected by Duchenne muscular dystrophy

Vincenzo Giglio, MD^*,*, Vincenzo Pasceri, MD, PhD, Loredana Messano, MD^*, Fortunato Mangiola, MD^*, Luciano Pasquini, MD^||, Antonio Dello Russo, MD^*, Antonello Damiani, MD^*, Massimiliano Mirabella, MD, PhD^*¶, Giuliana Galluzzi, MD, PhD^*¶, Pietro Tonali, MD^¶# and Enzo Ricci, MD^*¶

^* Center for Neuromuscular Diseases, Uildm, Rome, Italy
Division of Cardiology and ICU, St. Paolo Hospital Civitavecchia, Rome, Italy
Division of Cardiology, San Filippo Neri Hospital, Rome, Italy
Cardiovascular Diseases Department, Institute of Cardiology, Catholic University, Rome, Italy
^|| Division of Pediatric Cardiology, Bambino Gesù Hospital, Rome, Italy
^¶ Muscular Dystrophy Research Unit, Institute of Neurology, Catholic University, Rome, Italy
^# Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

View larger version (128K): [in a new window]   Figure 1 Plot of the cyclic variation of integrated backscatter (cvIBS) sampled on the inferior base segment and the calibrated integrated backscatter (cIBS) in a four-year-old Duchenne muscular dystrophy (DMD) child (upper curve) and in an age-matched control (lower curve). The cvIBS and cIBS values are respectively smaller and higher in the DMD child than in the control.

View larger version (8K): [in a new window]   Figure 2 A 16-segment model was used for ultrasound tissue characterization analysis. The myocardial segments sampled were as follows: alb = anterolateral base; alm = anterolateral mid; ia = inferior apex; ib = inferior base; ilm = inferolateral mid; im = inferior mid; la = lateral apex; plb = posterolateral base.

View larger version (27K): [in a new window]   Figure 3 (A) Cyclic variation of integrated backscatter (cvIBS): data distribution in Duchenne muscular dystrophy children (DMDch) and controls. (B) Calibrated integrated backscatter (cIBS): data distribution in DMDch and controls.