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Low body mass index is a risk factor forimpaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress

Yukihito Higashi, MD, PhD^*,*, Shota Sasaki, MD, Keigo Nakagawa, MD, Masashi Kimura, MD, Kensuke Noma, MD, Satoshi Sasaki, MD, Keiko Hara, MD, Hideo Matsuura, MD, PhD, Chikara Goto, RPT, MS, Tetsuya Oshima, MD, PhD, Kazuaki Chayama, MD, PhD and Masao Yoshizumi, MD, PhD^*

^* Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
Division of Physical Therapy, Institute of Health Sciences, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
Department of Clinical Laboratory Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan

View larger version (20K): [in a new window]   Figure 1 The forearm blood flow (FBF) response to acetylcholine (ACh) in low body mass index (BMI), normal, obese, and extremely obese subjects after adjustment for body weight.

View larger version (21K): [in a new window]   Figure 2 The forearm blood flow (FBF) response to isosorbide dinitrate (ISDN) in low body mass index (BMI), normal, obese, and extremely obese subjects after adjustment for body weight.

View larger version (20K): [in a new window]   Figure 3 The forearm blood flow (FBF) response to acetylcholine (ACh) in the presence of NG-monomethyl-L-arginine (L-NMMA) in low body mass index (BMI), normal, obese, and extremely obese subjects after adjustment for body weight.

View larger version (24K): [in a new window]   Figure 4 The effect of concomitant administration of the antioxidant, vitamin C, on the forearm blood flow (FBF) response to acetylcholine (ACh) administration in low body mass index (BMI), normal, obese, and extremely obese subjects.