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Long-term effectiveness of cardiac resynchronization therapy in patients with refractory heart failure and "narrow" QRS

Augusto Achilli, MD^*,*, Massimo Sassara, MD^*, Sabina Ficili, MD^*, Daniele Pontillo, MD^*, Paola Achilli, MD^*, Claudio Alessi, MD^*, Stefano De Spirito, MD^*, Roberto Guerra, MD^*, Nicolino Patruno, MD and Francesco Serra, MD^*

^* Cardiovascular Department, Belcolle Hospital, Viterbo, Italy
Cardiology Division, S.Giuseppe Hospital, Albano Laziale, Italy

View larger version (16K): [in a new window]   Figure 1 Baseline duration of QRS (white bars), interventricular delay (black bars), and posterolateral left ventricular wall activation delay (striped bars) in patients in group 1 with sinus rhythm (SR) at enrollment, with prior pacemaker implantation (PM), and in group 2. The only difference between the groups is represented by QRS duration (*p < 0.001 group 2 vs. RS and vs. PM).

View larger version (21K): [in a new window]   Figure 2 Regression lines (solid line = group 1; dashed line = group 2) show a fairly good correlation between the magnitude of interventricular delay decrease (IVD) and magnitude of ejection fraction increase (EF) (top) and left ventricular end-systolic diameter decrease (LVESD) (bottom) in group 1 (open squares) but not in group 2 (solid triangles) after cardiac resynchronization therapy. = follow-up – baseline absolute difference. *p value based on analysis of covariance.