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Prospective, randomized evaluation of thrombectomy prior to percutaneous intervention in diseased saphenous vein grafts and thrombus-containing coronary arteries

Gregg W. Stone, MD, FACC^*,*, David A. Cox, MD, FACC, Joseph Babb, MD, FACC, Dean Nukta, MD, FACC, Luc Bilodeau, MD^||, Louis Cannon, MD, FACC^¶, Thomas D. Stuckey, MD, FACC^#, James Hermiller, MD, FACC^**, Eric A. Cohen, MD, Reginald Low, MD, FACC, Steven R. Bailey, MD, FACC, Alexandra J. Lansky, MD, FACC^*, Richard E. Kuntz, MD, FACC^|||| for the X-TRACT Investigators

^* Cardiovascular Research Foundation and Lenox Hill Hospital, New York, New York, USA
Mid Carolina Cardiology, Charlotte, North Carolina, USA
Pitt County Memorial Hospital, Greenville, North Carolina, USA
Fairview Hospital, Cleveland, Ohio, USA
^|| Montreal Heart Institute, Montreal, Canada
^¶ St. Mary’s Hospital, Saginaw, Michigan, USA
^# Moses Cone Hospital, Greensboro, North Carolina, USA
^** St. Vincent’s Hospital, Indianapolis, Indiana, USA
Sunnybrook and Women’s College Health Sciences Center, Toronto, Canada
Mercy Hospital, Sacramento, California, USA
University of Texas Health Sciences Center, San Antonio, Texas, USA
^|||| Brigham and Women’s Hospital, Boston, Massachusetts, USA

View larger version (14K): [in a new window]   Figure 1 Cumulative frequency distribution curves of peak post-procedural creatine phosphokinase (CPK)-MB isoenzyme for patients randomized to thrombectomy with the X-SIZER device (open circles) versus control (closed circles). Each curve shows the percentage of patients whose CPK-MB elevation (expressed as a multiple of institutional upper limit of normal) exceeds the value on the x-axis.

View larger version (22K): [in a new window]   Figure 2 Incidence of large myocardial infarction at 30 days in patients randomized to thrombectomy with the X-SIZER device prior to stenting versus stenting without thrombectomy, stratified by baseline and procedural variables. Black bars = control; open bars = X-SIZER. Native = native coronary artery; PCI = percutaneous coronary intervention; RRR = relative risk reduction; SVG = saphenous vein graft.