Endothelin-1 regulates arterial pulse wave velocity in vivo
Carmel M. McEniery, PhD*,*,
Ahmad Qasem, PhD ,
Matthias Schmitt, MB, MRCP ,
Albert P. Avolio, PhD,
John R. Cockcroft, BSc, MB, FRCP and
Ian B. Wilkinson, MA, BM, MRCP*
* Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
Department of Cardiology, Wales Heart Research Institute, Cardiff, United Kingdom
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Figure 1 Schema showing drug infusions via the catheter (proximal) and sheath (distal). P1 = pressure sensor 1; P2 = pressure sensor 2.
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Figure 2 Experimental protocol. (A) Infusion of exogenous endothelin-1 (ET-1); (B) infusion of BQ-123.
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Figure 3 The effect of intra-arterial infusion of endothelin-1 (ET-1) via the catheter on iliac pulse wave velocity (PWV) (n = 6). Values represent means ± SD; p < 0.001 (ANOVA), compared with saline. *p < 0.01. **p < 0.001, Bonferroni test.
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Figure 4 The effect of intra-arterial infusion of BQ-123 through the sheath and catheter (triangles, n = 8), followed by endothelin-1 (ET-1) (open squares, n = 4), or saline (closed squares, n = 4) on iliac pulse wave velocity (PWV). Values represent means ± SD; p < 0.001 (ANOVA), compared with saline. *p < 0.001, Bonferroni test.
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