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The relationship between cholesterol and survival in patients with chronic heart failure

Mathias Rauchhaus, MD^*, Andrew L. Clark, MD^,*, Wolfram Doehner, MD^*, Constantinos Davos, MD, PhD^*, Aidan Bolger, BSc^*, Rakesh Sharma, BSc^*, Andrew J. S. Coats, DM^* and Stefan D. Anker, MD, PhD^*

^* Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
Klinik und Poliklinik für Innere Medizin III, Martin-Luther-Universität, Halle, Germany
Academic Cardiology, Castle Hill Hospital, Hull, United Kingdom
Franz-Volhard-Klinik (Charité, Campus Berlin-Buch) am Max-Delbrück Centrum für Molekulare Medizin, Berlin, Germany

View larger version (24K): [in a new window]   Figure 1 Survival in the derivation study with patients classified into quartiles of total cholesterol (quartile 1 being the lowest; 4 the highest). Log-rank p = 0.0016 for the differences between quartiles.

View larger version (15K): [in a new window]   Figure 2 Survival in the validation study related to the best predictive value for serum cholesterol found in the derivation study. Log-rank p = 0.0011 for the difference between groups.

View larger version (23K): [in a new window]   Figure 3 Survival by etiology and cholesterol in the validation study. Log-rank p = 0.05 for comparison between high and low cholesterol in nonischemic etiology and p = 0.001 for ischemic etiology.