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J Am Coll Cardiol, 2003; 42:1900-1905, doi:10.1016/j.jacc.2003.06.012
© 2003 by the American College of Cardiology Foundation
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Increased CK-MB release is a "trade-off" for optimal stent implantation

an intravascular ultrasound study

Ioannis Iakovou, MD*, Gary S. Mintz, MD*, George Dangas, MD, PhD*,*, Alexandre Abizaid, MD*, Roxana Mehran, MD*, Yoshio Kobayashi, MD*, Alexandra J. Lansky, MD*, Eve D. Aymong, MD, MSc*, Eugenia Nikolsky, MD*, Gregg W. Stone, MD*, Jeffrey W. Moses, MD* and Martin B. Leon, MD*

* Cardiovascular Research Foundation, Lenox Hill Heart and Vascular Institute, New York, New York, USA



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Figure 1 Creatine kinase-MB isoenzyme elevation (CK-MB) post percutaneous coronary intervention according to stent expansion. CK-MB release one to three times normal was similar in Group 1 (stent expansion <70%) vs. Group 2 (stent expansion 70% to 100%) vs. Group 3 (stent expansion >100%). However, there was a stepwise increase in CK-MB 3 to 5 times and >5 times normal in Group 1 vs. Group 2 vs. Group 3.

 


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Figure 2 One-year cumulative outcome. There was a stepwise decrease in death, multiple adverse cardiac events, and target lesion revascularization in Group 1 (stent expansion <70%) vs. Group 2 (stent expansion 70% to 100%) vs. Group 3 (stent expansion >100%). MACE = multiple adverse cardiac events; Q-W MI = Q-wave myocardial infarction; TLR = target lesion revascularization.

 


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Figure 3 The occurrence of any target lesion revascularization event decreased with increasing percent stent expansion (% stent expansion = final stent CSA/[proximal CSA + distal CSA]/2). CSA = cross-sectional area.

 





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