Time course of the interaction between tadalafil and nitrates
Robert A. Kloner, MD, PhD*,*,
Adolph M. Hutter, MD ,
Jeffrey T. Emmick, MD, PhD ,
Malcolm I. Mitchell, MBBS, MFPM ,
Jonathan Denne, PhD and
Graham Jackson, MD||
* The Heart Institute, Good Samaritan Hospital, Cardiovascular Division, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Eli Lilly and Company, Indianapolis, Indiana, USA
Erl Wood Manor, Windlesham, Surrey, United Kingdom;
|| Guys and St. Thomas Hospital, London, United Kingdom
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Figure 1 Mean standing systolic and diastolic blood pressure (BP) in tadalafil (20 mg)- and placebo-treated subjects. Sublingual nitroglycerin (0.4 mg) is indicated by the dashed vertical line. The 4- to 96-h time intervals represent time of nitroglycerin administration after the last dose of tadalafil or placebo. In each graph, the upper set of curves represent systolic BP and the lower set of curves represent diastolic BP. Standard deviation for systolic and diastolic BP ranged from 12 to 19 mm Hg and 9 to 13 mm Hg, respectively.
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Figure 2 Mean standing heart rate in tadalafil (20 mg)- and placebo-treated subjects. Sublingual nitroglycerin (0.4 mg) is indicated by dashed vertical line. The 4- to 96-h time intervals represent time of nitroglycerin administration after last dose of tadalafil or placebo. Standard deviation for time points ranged from 10 to 16 beats/min (bpm).
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