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Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care

A randomized, controlled trial

Susan P. Wright, MBChB^*, Robert N. Doughty, MD, MRCP, FRACP^*,*, Ann Pearl, MA (Hons), MBChB, Greg D. Gamble, MSc^*, Gillian A. Whalley, MHSci, DMU^*, Helen J. Walsh, BSc^*, Gary Gordon, MBChB, FCP(SA), FRACP^*, Warwick Bagg, MD, FRACP^*, Helen Oxenham, MBBS, MRCP^*, Tim Yandle, PhD, Mark Richards, MD, PhD, DSc, FACC, FRACP, FRSNZ and Norman Sharpe, MD, FRACP, FACC^*

^* Department of Medicine, University of Auckland, Auckland, New Zealand
Department of General Practice and Primary Health Care Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Christchurch CardioEndocrine Research Group, Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand

View larger version (25K): [in a new window]   Figure 1 Trial profile. GP = general practitioner; N-BNP = amino-terminal pro-brain natriuretic peptide.

View larger version (18K): [in a new window]   Figure 2 Receiver operating characteristic curve for N-BNP in the diagnosis of heart failure. Area under the curve = 0.85.