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Preserved response of mitochondrial function to short-term endurance training in skeletal muscle of heart transplant recipients

Joffrey Zoll, PhD^*,*, Benoit N’Guessan, BS^*, Florence Ribera, PhD^*, Eliane Lampert, MD^*, Dominique Fortin, Vladimir Veksler, MD, PhD, Xavier Bigard, MD, PhD, Bernard Geny, MD, PhD^*, Jean Lonsdorfer, MD, PhD^*, Renée Ventura-Clapier, PhD and Bertrand Mettauer, MD, PhD^*

^* Service de Physiologie Clinique et des Explorations Fonctionnelles, Département de Physiologie, Faculté de Médecine, Strasbourg, France
Cardiologie Cellulaire et Moléculaire, U-446 INSERM, Faculté de Pharmacie, Université Paris-Sud, Châtenay-Malabry, France
Unité de Bioénergétique, CRSSA, La-Tronche Cedex, France

View larger version (32K): [in a new window]   Figure 1 Parameters of mitochondrial respiration. Muscle fiber bundles were taken from the vastus lateralis of heart transplant recipients before and after training in the trained (T) group and at the same follow-up period in the untrained (UT) group. (A) Basal and maximum respiration (Vmax) (expressed in µmol O2/min per g dry weight) were measured in saponin-skinned fibers. (B) The acceptor control ratio (ACR) (Vmax/basal VO2). Data are expressed as the mean value ± SEM. *p < 0.05 vs. T before training.

View larger version (21K): [in a new window]   Figure 2 Apparent Michaelis-Menten constant (Km) for adenosine diphosphate (ADP)-stimulated respiration in the absence or presence of creatine. The Km (µmol/l) without creatine was increased after training (**p < 0.01). The addition of creatine significantly decreased the Km, but only after training (p < 0.01 vs. Km without creatine). Dotted bars = untrained (UT) group before training; bars with diagonal lines = UT group after training; open bars = trained (T) group before training; solid bars = T group after training.