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Predictors of cardiac morbidity and related mortality in children with acquired immunodeficiency syndrome

Inas Al-Attar, MD^*, E. John Orav, PhD^||, Vernat Exil, MD, Sarah A. Vlach, MD^*¶ and Steven E. Lipshultz, MD^*¶#,*

^* Department of Cardiology, Boston, Massachusetts, USA
Division of Infectious Diseases, Children’s Hospital USA
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
^|| Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
^¶ Division of Pediatric Cardiology, Golisano Children’s Hospital at Strong and University of Rochester Medical Center, Rochester, New York, USA
^# Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

View larger version (20K): [in a new window]   Figure 1 Survival time to death with cardiac dysfunction ("cardiac death") in AIDS patients. Curve B represents a typical AIDS patient in our cohort with all of the variables included in our multiple regression model for time to cardiac death in Table 5 set to average values. The average CD4 z-score in our cohort was approximately –2, and the average IgG z-score was approximately 3. Curve A represents a healthier AIDS patient with a CD4 z-score = –1 and an IgG z-score = 4 (all other covariates remain at average values). Curve C represents a sicker AIDS patient with a CD4 z-score = –3 and an IgG z-score = 2.