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The power of clinical trials and guidelines,and the challenge of conflicts of interest

^* Mayo Clinic, Division of Cardiovascular Diseases, Rochester, Minnesota, USA

View larger version (23K): [in a new window]   Figure 1 NHLBI total budget (decade subtotals in $ billion). Derived from NHLBI fiscal year 2002 fact book (Bethesda, Maryland), page 69.

View larger version (29K): [in a new window]   Figure 2 Number of clinical trials listed in Cardiovascular Trials Review (1996 to 2002 editions). *2002 total includes pre-1998 trials deleted in the 7th edition because of space (1,532 pages). Derived from Kloner RA, Birnbaum Y. Cardiovascular Trials Review. Darien, CT: Le Jacq Communications. Thanks to Robert A. Kloner, MD, PhD.