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The T^-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study

Gian Paolo Rossi, MD, FACC, FAHA^,*, Maurizio Cesari, MD, Mario Zanchetta, MD^*, Stefania Colonna, MD, Giuseppe Maiolino, MD, Luigi Pedon, MD^*, Martina Cavallin, BiolD, Pietro Maiolino, MD^* and Achille C. Pessina, MD, PhD

^* Servizio di Emodinamica and Divisione di Cardiologia Ospedale di Cittadella, University of Padova, Padova, Italy
Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Padova, Italy

View larger version (36K): [in a new window]   Figure 1 Results of the logistic regression analysis in the different risk subgroups of subjects and in subjects with concurrence of at least four major risk factors (top). The squares (closed for the T-786C C allele; open for the other variables) and the lines indicate, respectively, the value of the B coefficient (an estimate of the odds ratio) and its 95% confidence interval. For the purpose of visual clarity, the reciprocal value of the B coefficient that was <1 was used. The figure shows the independent variables that remained in the model, that is, were significant predictors of multivessel coronary artery disease (CAD) in each subgroup, ranked from bottom to top according to the value of the Wald coefficient. Notice the usefulness of T-786C polymorphism for the prediction of multivessel CAD in all subgroups. The coexistence of four major risk factors (subgroup at the top) resulted in a clear-cut increase of the odds ratio for C allele of the T-786C polymorphism, further confirming the usefulness of this endothelial nitric oxide synthase molecular variant for the prediction of multivessel CAD. HDL = high-density lipoprotein; LDL = low-density lipoprotein.