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Pulmonary function in primary pulmonary hypertension

^* Division of Respiratory and Critical Care Physiology and Medicine and Division of Cardiology, Department of Medicine, Research and Education Institute, Harbor–UCLA Medical Center, Torrance, California, USA

View larger version (29K): [in a new window]   Figure 1 Distribution of values for forced vital capacity (FVC) (upper) and gas transfer index or diffusing capacity for carbon monoxide (DLCO) (lower) in 79 primary pulmonary hypertension (PPH) patients (lines from upper left to lower right) and 20 normal controls (lines from lower left to upper right). Values are divided by deciles of percent predicted (%pred). For these measurements, all individuals below 80% of predicted are below the normal 95% confidence limits. Approximately 50% of the PPH patients have a reduced FVC and 75% have a reduced DLCO.

View larger version (31K): [in a new window]   Figure 2 Correlation of resting lung function measurements in 79 primary pulmonary hypertension (PPH) patients. Each symbol indicates an individual PPH patient. Upper left: Values are percent predicted (%pred) for FVC and FEV1; upper right: absolute values for FEV1 and MVV; lower left: absolute values for alveolar volume determined from single breath dilution of inert gas (VA') and TLC determined by body plethysmography or N2 washout method; and lower right: %pred values for DLCO and FVC. The mean ± SD of their sample ratio values are: FEV1/FVC = 0.99 ± 0.09, MVV/FEV1 = 39 ± 7, and VA'/TLC = 0.96 ± 0.03. Solid lines are the regressions lines for the data; dotted lines are the lines of identity. DLCO = gas transfer index; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity; MVV = maximum voluntary ventilation; TLC = total lung capacity; VA' = effective alveolar volume.

View larger version (19K): [in a new window]   Figure 3 Correlations and regression equations for gas transfer index (DLCO) versus three cardiopulmonary exercise test parameters of aerobic function (upper = peak O2 uptake; middle = anaerobic threshold; lower = peak O2 pulse) in primary pulmonary hypertension (PPH) patients. Each symbol indicates an individual PPH patient. All values and equations are in units of % predicted (%pred). Dotted lines approximate the 95% confidence limits of controls.