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Glycoprotein IIb/IIIa inhibition in early intent-to-stent treatment of acute coronary syndromes: EPISTENT, ADMIRAL, CADILLAC, and TARGET

^* Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

View larger version (18K): [in a new window]   Figure 1 Primary and secondary end points at 30 days in the Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes V trial. Recorded on day 7 or at discharge, whichever was earlier. MI = myocardial infarction; PCI = percutaneous coronary intervention. Reprinted with permission from Elsevier Science (Lancet 2001;357:1905–14).

View larger version (8K): [in a new window]   Figure 2 Association of myocardial blush (microvascular perfusion) and mortality among myocardial infarction patients with Thrombolysis In Myocardial Infarction grade 3 flow undergoing emergent percutaneous transluminal coronary angioplasty. Adapted with permission from the American College of Cardiology Foundation, J Am Coll Cardiol 2000;35:403A.

View larger version (20K): [in a new window]   Figure 3 Death, re-infarction, or urgent target vessel revascularization (TVR) at 30 days using adjunctive abciximab for percutaneous coronary intervention in acute myocardial infarction (MI) trials. Open bars = placebo; closed bars = abciximab. ADMIRAL = Abciximab before Direct angioplasty and stenting in Myocardial Infraction Regarding Acute and Long-term follow-up trial; CADILLAC = Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications trial; ISAR = Intracoronary Stenting and Antithrombotic Regimen trial; PTCA = percutaneous transluminal coronary angioplasty; RAPPORT = ReoPro And Primary PTCA Organization and Randomized Trial.

View larger version (17K): [in a new window]   Figure 4 Achievement of Thrombolysis In Myocardial Infarction (TIMI) 3 flow with abciximab in Abciximab before Direct angioplasty and stenting in Myocardial Infraction Regarding Acute and Long-term follow-up (ADMIRAL) trial. Open bars = placebo; closed bars = abciximab. Adapted with permission, 2002, from Montalescot G, Barragan P, Wittenberg O, et al. Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction. N Engl J Med 2001;334:1895–903. Copyright 2001 Massachusetts Medical Society. All rights reserved.