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Fibrinolysis of mechanical prosthetic valve thrombosis

A single-center study of 127 cases

Raymond Roudaut, MD, FESC^*,*, S. téphane Lafitte, MD, PhD^*, Marie-Françoise Roudaut, MD^*, Carine Courtault, MD^*, Jean-Marie Perron, MD^*, Catherine Jaïs, MD^*, Xavier Pillois, PhD^*, Pierre Coste, MD^* and Anthony DeMaria, MD, FACC

^* Hôpital Cardiologique Haut-Lévêque, Pessac, France
Cardiology Department, University of California San Diego, San Diego, California, USA

View larger version (15K): [in a new window]   Figure 1 Fibrinolysis of prosthetic valve thrombosis: distribution of cases over time (1978 to 2001) in our institution.

View larger version (10K): [in a new window]   Figure 2 Efficacy of fibrinolysis of prosthetic valve thrombosis.

View larger version (18K): [in a new window]   Figure 3 Efficacy according to fibrinolytic agent: on the left, after the first single fibrinolysis treatment (FT); on the right, after complementary FT (combined therapy). rtPA = recombinant tissue-type plasminogen activator; SK = streptokinase; UK = urokinase.

View larger version (11K): [in a new window]   Figure 4 Treatment algorithm for left-sided prosthetic heart valve thrombosis. TEE = transesophageal echocardiography.