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Duration of abnormal SPECT myocardial perfusion imaging following resolution of acute ischemia: an angioplasty model

Daniel B. Fram, MD, FACC^*,*, Rabih R. Azar, MD^*, Alan W. Ahlberg, MA^*, Linda D. Gillam, MD, FACC^*, Joseph F. Mitchel, DO, FACC^*, Francis J. Kiernan, MD, FACC^*, Jeffrey A. Hirst, MD, FACC^*, Jeffrey F. Mather, MS^*, Edward Ficaro, PhD^*, Gizelle Cyr, RN^*, David Waters, MD, FACC^* and Gary V. Heller, MD, PhD, FACC^*

^* Nuclear Cardiology, Cardiac Catheterization, and Echocardiography Laboratories of the Henry Low Heart Center, Hartford Hospital, Hartford, Connecticut, USA
University of Connecticut School of Medicine, Farmington, Connecticut, USA

View larger version (16K): [in a new window]   Figure 1 Nuclear injection protocol (details in the text). PCI = percutaneous coronary intervention.

View larger version (19K): [in a new window]   Figure 2 Decrease over time in the number of abnormal nuclear scans and the intensity of the nuclear defects. *p < 0.001 vs. acute; p = 0.01 vs. acute; p < 0.001 vs. all delayed (15 min and 1 to 3 h); ¶p < 0.01 vs. all delayed (15 min and 1 to 3 h); p = 0.03 vs. 15 min group.

View larger version (111K): [in a new window]   Figure 3 Myocardial perfusion imaging in a patient who underwent angioplasty of the left anterior descending coronary artery with delayed imaging at 1 h. Acute imaging revealed a marked perfusion defect involving the anterior septum, anterior wall, and apex. Delayed imaging revealed a substantially less intense defect in this distribution and late imaging revealed normal perfusion.

View larger version (108K): [in a new window]   Figure 4 Myocardial perfusion imaging in a patient who underwent angioplasty of the right coronary artery with delayed imaging at 3 h. Acute imaging revealed a marked perfusion defect involving the inferior wall and the inferior septum. Delayed imaging revealed a substantially less intense defect in this distribution and late imaging revealed normal perfusion.