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Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes

Sotirios Tsimikas, MD, FACC^*,*, Claes Bergmark, MD, Reinaldo W. Beyer, MD, FACC^*, Raj Patel, MD^*, Jennifer Pattison, BS^*, Elizabeth Miller, BS^*, Joseph Juliano, BS^* and Joseph L. Witztum, MD^*

^* Department of Medicine, University of California at San Diego, La Jolla, California, USA
Department of Vascular Surgery, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden

View larger version (31K): [in a new window]   Figure 1 Percent change from baseline in individual immunoglobulin (Ig)M oxidized low-density lipoprotein (OxLDL) autoantibody titers. The p values at the 30-, 120-, and 210-day labels represent differences between groups at each time point. **p < 0.01 for differences within individuals groups. CAD = coronary artery disease; Cu-LDL = copper oxidized low-density lipoprotein; MDA-LDL = malondialdehyde-low-density lipoprotein; MI = myocardial infarction; POVPC = 1-palmitoyl-2-(5-oxovaleryoyl)-phosphatidylcholine.

View larger version (26K): [in a new window]   Figure 2 Percent change from baseline in mean immunoglobulin (Ig)M oxidized low-density lipoprotein (OxLDL) autoantibody titers (A) and IgM low-density lipoprotein (LDL)-immune complexes (B). The p values at the 30-, 120-, and 210-day labels represent differences between groups at each time point. *p < 0.05, **p < 0.01, and ***p < 0.001 for differences within individual groups. CAD = coronary artery disease; MI = myocardial infarction; UNSA = unstable angina.

View larger version (27K): [in a new window]   Figure 3 Percent change from baseline in mean immunoglobulin (Ig)G oxidized low-density lipoprotein (OxLDL) autoantibody titers (A) and IgG low-density lipoprotein (LDL)-immune complexes (B). The p values at the 30-, 120-, and 210-day labels represent differences between groups at each time point. *p < 0.05, **p < 0.01, and ***p < 0.001 for differences within individual groups. CAD = coronary artery disease; MI = myocardial infarction; UNSA = unstable angina.

View larger version (20K): [in a new window]   Figure 4 Percent change from baseline in oxidized low-density lipoprotein measured by antibody E06 (OxLDL-E06) (A), lipoprotein(a) (Lp[a]) (B), and low-density lipoprotein (LDL) cholesterol levels (C). The p values at the 30-, 120-, and 210-day labels represent differences between groups at each time point. *p < 0.05 for differences within individual groups. CAD = coronary artery disease; MI = myocardial infarction.

View larger version (18K): [in a new window]   Figure 5 Correlation between plasma lipoprotein(a) (Lp[a]) and oxidized low-density lipoprotein measured by antibody E06 (OxLDL-E06) levels, defined as the ratio of E06 to apolipoprotein (apo) B-100 and measured as relative light units, as described in the Methods section. The results from each time point for all of the patients are combined and analyzed simultaneously.