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Acute systemic inflammation enhances endothelium-dependent tissue plasminogen activator release in men

Stanley Chia, MB, ChB (Hons), MRCP^*,*, Christopher A. Ludlam, MB, ChB, PhD, FRCP, FRCPath, Keith A. A. Fox, BSc (Hons), MB, ChB, FRCP, FESC^* and David E. Newby, BA, BSc (Hons), PhD, BM, DM, MRCP^*

^* Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
Department of Haematology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

View larger version (19K): [in a new window]   Figure 1 Infused forearm blood flow during bradykinin (circles), acetylcholine (triangles), and sodium nitroprusside (squares) infusions in subjects who were administered typhoid vaccination (closed symbols) and saline placebo (open symbols). Analysis of variance, p < 0.001 for all (dose-response).

View larger version (17K): [in a new window]   Figure 2 Estimated net release of tissue-type plasminogen activator (t-PA) antigen (solid line) and activity (dotted line) in subjects who were administered typhoid vaccination (closed circles and bars) and saline placebo (open circles and bars). Lower panel represents area under the curve for the response. Analysis of variance, *p < 0.05; p = 0.006 (vaccination vs. placebo); t test, p < 0.05 (vaccination vs. placebo).