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Impact of aging on substrate metabolism by the human heart

Andrew M. Kates, MD, Pilar Herrero, MS^*, Carmen Dence, MS^*, Pablo Soto, MD, Muthayyah Srinivasan, MD, Deborah G. Delano, RN, MHS^*, Ali Ehsani, MD, FACC and Robert J. Gropler, MD, FACC^*,*

^* Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, St. Louis, Missouri, USA
Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

View larger version (9K): [in a new window]   Figure 1 Average values and standard deviations for the levels of myocardial blood flow (MBF) and oxygen consumption (MVO2) for the younger and older subjects. Although MBF was similar between the groups, MVO2 was higher in the older subjects compared with the younger subjects. *p < 0.05. Open bar = younger subjects; solid bar = older subjects.

View larger version (14K): [in a new window]   Figure 2 Average values and standard deviations for the levels of myocardial fatty acid utilization (MFAU) and oxidation (MFAO) and myocardial glucose utilization (MGU). The MFAU and MFAO did not differ between the groups, whereas MGU was higher in the older group compared with the younger group. *p < 0.05. Open bar = younger group; solid bar = older group.

View larger version (13K): [in a new window]   Figure 3 Values for myocardial fatty acid utilization (MFAU) and oxidation (MFAO) and myocardial glucose utilization (MGU) all corrected for myocardial oxygen consumption (MVO2). Both MFAU/MVO2 and MFAO/MVO2 were lower in the older subjects compared with younger subjects. The MGU/MVO2 did not differ between the groups. FFA = free fatty acids. *p < 0.005; **p < 0.004. Open bar = younger subjects; solid bar = older subjects.

View larger version (20K): [in a new window]   Figure 4 Correlation between plasma lactate levels and values for myocardial fatty acid utilization (MFAU) and oxidation (MFAO) and myocardial glucose utilization (MGU) all corrected for myocardial oxygen consumption (MVO2) in both younger and older subjects. There was no relationship between the plasma lactate level and MFAU/MVO2 (A), MFAO/MVO2 (B), MGU/MVO2 (C).