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Amiodarone versus placebo and class ic drugs for cardioversion of recent-onset atrial fibrillation: a meta-analysis

Philippe Chevalier, MD, PhD^*,*, Alexis Durand-Dubief, MD^*, Haran Burri, MD^*, Michel Cucherat, MD, Gilbert Kirkorian, MD^* and Paul Touboul, MD^*

^* Département de cardiologie et de soins intensifs, Hôpital Louis Pradel, Lyon, France
Service de pharmacologie clinique–EA 643 et Service de Biostatistique, Hôpitaux de Lyon, Lyon, France

View larger version (18K): [in a new window]   Figure 1 Amiodarone versus placebo showing no efficacy for return to sinus rhythm at 1 to 2 h (left) and efficacy at 24 h (right). Graphical representation shows relative risk and 95% confidence interval.

View larger version (18K): [in a new window]   Figure 2 Amiodarone versus class Ic drugs showing a greater efficacy of class Ic drugs for return to sinus rhythm at 1 to 2 h (left) but no difference at 24 h (right). Graphical representation shows relative risk and 95% confidence interval.