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Plasma natriuretic peptide levels increase with symptoms and severity of mitral regurgitation

Timothy M. Sutton, MB, ChB^*, Ralph A. H. Stewart, MD^,*, Ivor L. Gerber, MB, ChB, Teena M. West, MSc, A. Mark Richards, MD, DSc, Timothy G. Yandle, PhD and Andrew J. Kerr, MB, ChB^*

^* Cardiology Department, Middlemore Hospital, Auckland, New Zealand
Cardiology Department, Green Lane Hospital, Auckland, New Zealand
Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand

View larger version (26K): [in a new window]   Figure 1 Association between plasma brain natriuretic peptide (BNP) levels and (A) vena contracta width, (B) left ventricular end-systolic dimension, and (C) left atrial dimension in asymptomatic (open circles) and symptomatic (closed circles) patients with mitral regurgitation. The dashed lines indicate the upper limit of the normal laboratory reference range for BNP. Continued on next page.

View larger version (14K): [in a new window]   Figure 2 Sensitivity and specificity of brain natriuretic peptide (BNP), left atrial dimension, vena contracta width, and left ventricular (LV) end-systolic dimension for symptoms in patients with mitral regurgitation.