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J Am Coll Cardiol, 2003; 41:2093-2099, doi:10.1016/S0735-1097(03)00429-7
© 2003 by the American College of Cardiology Foundation
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Early outcome after sirolimus-eluting stent implantation in patients with acute coronary syndromes

Insights from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry

Pedro A. Lemos, MD*, Chi-hang Lee, MBBS, MRCP*, Muzaffer Degertekin, MD*, Francesco Saia, MD*, Kengo Tanabe, MD*, Chourmouzios A. Arampatzis, MD*, Angela Hoye, MB ChB, MRCP*, Marco van Duuren*, Giorgios Sianos, MD*, Pieter C. Smits, MD, PhD*, Pim de Feyter, MD, PhD*, Willem J. van der Giessen, MD, PhD*, Ron T. van Domburg, PhD* and Patrick W. Serruys, MD, PhD, FESC, FACC*,*

* Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands



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  		Figure 1 Cumulative major adverse cardiac events (MACE) rate (death, nonfatal myocardial infarction, or re-intervention) during the first month for control patients (bare stent) and patients treated with sirolimus-eluting stents (SES). Note that >50% of events occurred during the first week in both groups.

 


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  		Figure 2 Multivariate independent predictors of 30-day major adverse cardiac events (MACE) rate (death, nonfatal myocardial infarction, and re-intervention) derived from the final logistic regression model. The odds ratios (OR) are shown on logarithmic scale together with their 95% confidence interval (CI).

 


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  		Figure 3 Comparison of the strength (chi-square values) for the prediction of 30-day major adverse cardiac events (MACE) rate (death, nonfatal myocardial infarction, and re-intervention) of multivariate models. Model 1 is the final model selected in the logistic regression analysis and included the variables displayed in Figure 2. The forced inclusion of sirolimus-eluting stent (SES) utilization (Model 2) did not enhance the predictive strength of the model, as reflected by the negligible change in the chi-square values.

 




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Copyright © 2003 by the American College of Cardiology Foundation.