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Anemia predicts mortality in severe heart failure

The prospective randomized amlodipine survival evaluation (PRAISE)

Dariush Mozaffarian, MD, MPH^*,*, Regina Nye, MPH and Wayne C. Levy, MD

^* Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
Division of Cardiology, University of Washington, Seattle, USA
Pfizer PGRD, New London, Connecticut, USA

View larger version (17K): [in a new window]   Figure 1 Kaplan-Meier survival according to quintiles of hematocrit. *p = 0.004 for equality of survivor functions.

View larger version (16K): [in a new window]   Figure 2 Mortality rates according to deciles of hematocrit (Hct). Compared with the reference group (tenth decile, Hct >48.3%), higher mortality was only present in the first decile (Hct <35.4%), in which there was a 72% higher risk of death (hazard ratio 1.72, 95% confidence interval 1.13 to 2.62) after adjustment for potential confounders (Table 2, footnote).

View larger version (17K): [in a new window]   Figure 3 Mortality rates by cause of death, according to quintiles of hematocrit. Hematocrit was inversely associated with pump failure death (black bars) (p for trend <0.001). In contrast, there was a suggestion of a U-shaped relationship with sudden deaths (white bars) and other deaths (striped bars) (see text).