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Serum levels of carbohydrate antigen 125 in patients with chronic heart failure

Relation to clinical severity, hemodynamic and Doppler echocardiographic abnormalities, and short-term prognosis

Antonio D’Aloia, MD^*, Pompilio Faggiano, MD^,*, Gerard Aurigemma, MD, FACC, Luca Bontempi, MD^*, Giuseppina Ruggeri, MD, Marco Metra, MD^*, Savina Nodari, MD^* and Livio Dei Cas, MD^*

^* Cattedra di Cardiologia, Università di Brescia, Brescia, Italy
Unità Operativa di Policardiografia, Brescia, Italy
III Laboratorio di Analisi, Spedali Civili, Brescia, Italy
Cardiology Division, University of Worcester, Worcester, Massachusetts, USA

View larger version (13K): [in a new window]   Figure 1 Serum levels of carbohydrate antigen 125 (CA125) in congestive heart failure patients classified according to the different New York Heart Association (NYHA) functional classes. Data are expressed as the mean value ± SD. Difference between groups were assessed using analysis of variance with post hoc Scheffé correction. See text for details.

View larger version (35K): [in a new window]   Figure 2 Changes in serum levels of carbohydrate antigen 125 (CA125) after optimization of medical therapy for congestive heart failure. The left panel presents data from the patients in whom a clinical improvement after therapy was observed. The right panel presents data from the patients in whom no clinical improvement, or even a worsening, was observed despite intensive medical treatment. See text for details.

View larger version (20K): [in a new window]   Figure 3 Kaplan-Meier curves for congestive heart failure patients classified according to baseline serum levels of carbohydrate antigen 125 (CA125). See text for details. Cumulative proportion surviving: open circles = complete; solid plus signs = censored.