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Intravascular brachytherapy for native coronary ostial in-stent restenotic lesions

Costantino O. Costantini, MD^*, Alexandra J. Lansky, MD^*,*, Gary S. Mintz, MD, FACC^*, Kazuyuki Shirai, MD^*, George Dangas, MD, FACC^*, Roxana Mehran, MD, FACC^*, Martin Fahy, PhD^*, Steven Slack, MS^*, Maria Coral, MD^*, Paul S. Teirstein, MD, FACC^*, Ron Waksman, MD, FACC, Gregg Stone, MD, FACC^*, Jeffrey Moses, MD, FACC^* and Martin B. Leon, MD, FACC^*

^* Cardiovascular Research Foundation, Lenox Hill Hospital, New York, New York, USA
Department of Internal Medicine (Cardiology Division) from the Washington Hospital Center, Washington, DC, USA

View larger version (15K): [in a new window]   Figure 1 Comparison of the angiographic lesion length at baseline and follow-up in gamma-, beta-, and placebo-treated patients. VBT = vascular brachytherapy.

View larger version (19K): [in a new window]   Figure 2 Side branch angiographic diameter stenosis (DS %) post-intervention and at follow-up. White bars = gamma vascular brachytherapy (VBT) (n = 13); striped bars = beta VBT (n = 6); black bars = placebo (n = 21).

View larger version (14K): [in a new window]   Figure 3 Frequency of the proximal radiation fall-off zone occurring or not occurring in the analyzed population. According to the location of the proximal edge of the radiation source in relation to the coronary vasculature, the proximal radiation fall-off zone (represented by the ellipse surrounding the proximal source edge) was either present (right) or not present (left).

View larger version (13K): [in a new window]   Figure 4 Rate of restenosis (RS) occurring at the proximal and distal radiation fall-off zones in gamma-, beta-, and placebo-treated patients. The rates of restenosis where a fall-off of the radiation dose occurs (ellipse surrounding each radiation source edge) are shown in the graphic. Black bars = gamma vascular brachytherapy (VBT); striped bars = beta VBT; black bars = placebo.