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Brugada syndrome: 1992–2002

A historical perspective

Charles Antzelevitch, PhD, FACC^*,*, Pedro Brugada, MD, PhD, Josep Brugada, MD, PhD, Ramon Brugada, MD, FACC^*, Jeffrey A. Towbin, MD, FACC and Kolawanee Nademanee, MD, FACC^||

^* Masonic Medical Research Laboratory, Utica, New York, USA
Cardiovascular Center, OLV Hospital, Aalst, Belgium
Cardiovascular Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain
Pediatrics Department, Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA
^|| Pacific Rim Cardiac Electrophysiology and Research, Inglewood, California, USA

View larger version (89K): [in a new window]   Figure 1 Precordial leads of a patient with Brugada syndrome. Note the dynamic electrocardiographic (ECG) changes in the course of a week. Three distinct patterns are apparent. Arrows denote the J-wave. The left panel shows a type 1 ECG, whereas the middle and right panels depict type 2 and 3 Brugada ECGs. Reproduced from reference 39, with permission.

View larger version (25K): [in a new window]   Figure 2 Schematic representation of right ventricle epicardial action potential (AP) changes thought to underlie the electrocardiographic (ECG) manifestation of Brugada syndrome. Modified from reference 28, with permission.