Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?
Armin Zittermann, PhD*,*,
Stefanie Schulze Schleithoff*,
Gero Tenderich, MD ,
Heiner K. Berthold, MD, PhD ,
Reiner Körfer, MD and
Peter Stehle, PhD*
* Department of Nutrition Science, University of Bonn, Germany
Heart and Diabetes Center North Rhine-Westfalia, Department of Thoracic and Cardiovascular Surgery, Ruhr-University of Bochum, Bad Oeynhausen, Germany
Center for Cardiovascular Diseases, Department Clinical Pharmacology, Rotenburg a.d. Fulda, Germany
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Figure 1 Circulating concentrations (mean ± SD) of 25-hydoxyvitamin D (A) and calcitriol (B) in congestive heart failure (CHF) patients and in elderly healthy controls ( 50 years). Main effects of study groups were observed (analysis of variance; p < 0.001). ***Significant differences between CHF patients and elderly controls, p < 0.001 (post hoc Tukey test); **Significant difference between CHF patients and elderly controls, p < 0.025 (post hoc Tukey test).
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Figure 2 Blood concentrations (mean ± SD) of N-terminal pro-atrial natriuretic peptide (NT-proANP) in congestive heart failure (CHF) patients and in elderly healthy controls (50 years). Main effects of study groups were observed (analysis of variance; p < 0.001). ***Significant differences between CHF patients and elderly controls, p < 0.001 (post hoc Tukey test).
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Figure 3 Association between serum N-terminal pro-atrial natriuretic peptide (NT-proANP) and serum 25-hydroxyvitamin D values (r2 = 0.16; p < 0.001; regression equation: NT-proANP 4.14·25OHD–0.741).
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