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Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction

An experimental serial cardiac magnetic resonance imaging study

Matthias Nahrendorf, MD^*,*, Kai Hu, MD^*, Karl-Heinz Hiller, PhD, Paolo Galuppo, PhD^*, Daniela Fraccarollo, PhD^*, German Schweizer^*, Axel Haase, PhD, Georg Ertl, MD^*, Wolfgang R. Bauer, MD, PhD^* and Johann Bauersachs, MD^*

^* Medizinische Universitätsklinik Würzburg, Germany
Experimentelle Physik 5, Universität Würzburg, Würzburg, Germany

View larger version (70K): [in a new window]   Figure 1 Typical mid-ventricular diastolic and systolic short-axis slices 12 weeks after myocardial infarction. Heart from a rat treated with cerivastatin (myocardial infarction size 40%).

View larger version (17K): [in a new window]   Figure 2 Hypertrophy after myocardial infarction (MI). (A) Increase in left ventricular (LV) mass (mg) from 4 to 12 weeks after MI. (B) Change in wall thickness (mm) in the remote region. Data are presented as the mean value ± SEM. *p < 0.05 vs. Sham Plac, Sham Cer, and MI Cer. Cer = cerivastatin; Plac = placebo.

View larger version (35K): [in a new window]   Figure 3 Representative autoradiograph and statistical analysis showing the effects of long-term therapy with cerivastatin after myocardial infarction (MI) on left ventricular (LV) gene expression (n = 5 or 6 per group) of the iso-messenger ribonucleic acids for skeletal and cardiac alpha-actin. Two representative lanes are shown for each group, each from a separate rat. *p < 0.05 vs. Sham Plac. p < 0.05 vs. MI Plac. Cer = cerivastatin; Plac = placebo.

View larger version (21K): [in a new window]   Figure 4 Dilation after myocardial infarction (MI). (A) Increase in end-diastolic volume (µl) from 4 to 12 weeks after MI. (B) Ejection fraction (%) 12 weeks after MI. Data are presented as the mean value ± SEM. *p < 0.05 vs. Sham Plac and Sham Cer. p < 0.05 vs. MI Cer. Cer = cerivastatin; Plac = placebo.

View larger version (18K): [in a new window]   Figure 5 Left ventricular function. (A) Cardiac output (ml/min) 12 weeks after myocardial infarction (MI). *p < 0.05 vs. MI Plac and MI Cer plus L-NAME. (B) Systolic wall thickening (%) in the remote region 12 weeks after MI. Data are presented as the mean value ± SEM. *p < 0.05 vs. Sham Plac.