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Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A_2A-receptor–mediated coronary vasodilation

^* Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia, USA

View larger version (36K): [in a new window]   Figure 1 Effect of increasing verapamil infusion rates on resting left anterior descending coronary artery (LAD) flow and on the adenosine (A) and ATL-146e (B) flow responses. Results were expressed as % increase. Data are mean ± SEM of four experiments. *p < 0.05 vs. baseline. p < 0.05 vs. control vasodilation.

View larger version (22K): [in a new window]   Figure 2 Effect of verapamil infusion on the adenosine-induced (250 µg/kg/min) increase in microsphere-determined absolute regional myocardial blood flow in dogs with a critical left anterior descending coronary artery (LAD) stenosis. With verapamil, there was a severe impairment of the adenosine-mediated increase in normal left circumflex coronary artery (LCx) zone flow, resulting in a marked diminution of the LAD to LCx zone flow disparity. Data are mean ± SEM of two experiments. *p < 0.05 vs. baseline.

View larger version (45K): [in a new window]   Figure 3 Effect of reversing the verapamil (0.02 mg/kg/min)-induced mean arterial pressure (MAP) drop with calcium infusion (3.0 mg/kg/min) on adenosine (A) and ATL-146e (B) flow responses. Note that the vasodilator action of both adenosine and ATL-146e was not restored despite the recovery in MAP, indicating that the blunted coronary flow response was not caused by the verapamil-induced drop in pressure. Data are mean ± SEM of four experiments. *p < 0.05 vs. control.

View larger version (23K): [in a new window]   Figure 4 Attenuation of coronary flow responses to adenosine (n = 2) and the KATP channel activator pinacidil (n = 3) by glybenclamide and verapamil, respectively. *p < 0.05 vs. baseline. p < 0.05 vs. pinacidil. LAD = left anterior descending coronary artery.