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Cardiac manifestations of Anderson–Fabry disease in heterozygous females

Christoph Kampmann, MD^*,*, Frank Baehner, MD^*, Catharina Whybra^*, Claudia Martin, MD^*, Christiane M. Wiethoff^*, Markus Ries, MD^*, Andreas Gal, MD, PhD and Michael Beck, MD, PhD^*

^* Division of Cardiology and Division of Lysosomal Storage Diseases, University Children’s Hospital, Mainz, Germany
Institute of Human Genetics, University of Hamburg, Hamburg, Germany

View larger version (16K): [in a new window]   Figure 1 Left ventricular mass (LVM) corrected for height plotted against age in 55 patients. There are two benchmark lines included: one at 47 g/m2.7, indicating the normal limits of LVM. Above 38.2 years of age, 25 of 28 (89.3%) patients had an increased LVM, as did 25 of 25 (100%) patients above 45 years of age. Below 38 years of age, 12 of 27 (44.4%) patients had a normal LVM.