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Thrombolytic therapy of pulmonary embolism

A meta-analysis

Gabriel Thabut, MD^*,*, Dominique Thabut, MD, Robert P. Myers, MD, Brigitte Bernard-Chabert, MD, Rolana Marrash-Chahla, MD^*, Hervé Mal, MD^* and Michel Fournier, MD^*

^* Service de Pneumologie et Réanimation Respiratoire, Hôpital Beaujon, Clichy, France
Service d’Hépato-Gastroentérologie, Hôpital Pitié-Salpêtrière, Paris, France

View larger version (25K): [in a new window]   Figure 1 Graphic representation of the relative risk (95% confidence interval [CI]) of mortality in the thrombolysis versus heparin groups.

View larger version (19K): [in a new window]   Figure 2 Graphic representation of the relative risk (95% confidence interval [CI]) of the recurrence of pulmonary embolism in the thrombolysis versus heparin groups.

View larger version (24K): [in a new window]   Figure 3 Graphic representation of the relative risk (95% confidence interval [CI]) of major hemorrhage in the thrombolysis versus heparin groups.

View larger version (9K): [in a new window]   Figure 4 Funnel-plot analysis. Plot of the logarithm of the relative risk of mortality versus precision of the included trials. The study by Marini et al. (7) was excluded because the relative risk could not be calculated, as no deaths occurred in either treatment group. The funnel plot is symmetrical (intercept 0.15; 95% confidence interval –1.06 to 1.37), contradicting the presence of a publication bias.