Relationship between residual atheroma burden and neointimal growth in patients undergoing stenting
Analysis of the atherectomy before MULTI-LINK improves lumen gain and clinical outcomes trial intravascular ultrasound substudy
Ivan P. Casserly, MB BCh*,
Herbert D. Aronow, MDMPH*,
Paul Schoenhagen, MD*,
Hiroshi Tsutsui, MD*,
Jennifer Popovich, BA*,
Marlene Goormastic, MPH*,
Jeffrey J. Popma, MD, FACC ,
Steven E. Nissen, MD, FACC* and
E. Murat Tuzcu, MD, FACC*,*
* Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Department of Cardiology, Brigham and Women’s Hospital, Boston, Massachusetts, USA
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Figure 1 Intravascular ultrasound images obtained postintervention and at follow-up demonstrating the measurements performed by manual planimetry at each time point. EEM = external elastic membrane area.
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Figure 2 Cross-sectional intravascular ultrasound image obtained at six months follow-up illustrating the method used to examine the circumferential relationship of atheroma and neointima. The vessel is divided into quadrants with the first quadrant containing the maximum of atheroma. Lumen, external elastic membrane cross-sectional area (EEM), atheroma and neointimal areas are planimetered in each quadrant as illustrated.
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Figure 3 Relationship between percent atheroma and neointimal areas in a pooled analysis of all cross sections at follow-up; n = 626, r = 0.11.
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Figure 4 Relationship of percent atheroma volume postintervention and percent neointimal volume at follow-up in 26 patients with volumetric data; n = 26, r = 0.1, p = 0.62.
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