Left ventricular pressure-volume relationship in a murine model of congestive heart failure due to acute viral myocarditis
Ryosuke Nishio, MD, PhD*,
Shigetake Sasayama, MD, PhD, FACC* and
Akira Matsumori, MD, PhD, FACC*,*
* Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
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Figure 1 Volume calibration of the conductance catheter. The absolute volume in each cylinder was plotted against the raw signals of conductance acquired by the conductance catheter. The regression formula,  (R2 = 0.969; p < 0.01) was used to calculate the raw and parallel volumes.
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Figure 2 Pressure-volume relations, left ventricular (LV) pressure, and slope of derivative of change in systolic pressure over time (dP/dt) curves in control versus infected groups. A, C, E = pressure-volume relations. Light continuous curves are data from the uninfected control group. Continuous curves are data from the infected group. Dotted lines indicate end-systolic and end-diastolic pressure volume relationships. B, D, F = LV pressure and dP/dt curves. A, B = day 1; C, D = day 7; E, F = day 14.
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Figure 3 Evolution of contractility, myocardial relaxation, and chamber compliance. Open circles = uninfected control group; solid circles = infected group. dP/dtmax = slope of maximum derivative of change in systolic pressure over time; dP/dtmin = minimum derivative of change in diastolic pressure over time; NL Eed = normalized end-diastolic volume elastance; NL Ees = normalized end-systolic volume elastance. *p < 0.05; **p < 0.01 versus control. n = 5 in each measurement.
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Figure 4 Evolution of left ventricular pressure and volume. (A) Pressure measurements. Circles = end-systolic pressure (ESP); squares = end-diastolic pressure (EDP). (B) Volume measurements. Solid circles = end-diastolic volume (EDV); squares = end-systolic volume (ESV); open circles = control group; solid circles = infected group. *p < 0.05; **p < 0.01 versus control. n = 5 in each measurement.
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Figure 5 Evolution of cardiac output, ejection fraction (EF), and left ventricular work efficiency. Open circles = uninfected control group; solid circles = infected group. *p < 0.05; **p < 0.01 versus control. n = 5 in each measurement. CI = cardiac index.
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Figure 6 Pathophysiologic manifestations during three phases of acute encephalomyocarditis virus-induced myocarditis.
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