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Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with ³¹P-SLOOP magnetic resonance spectroscopy

Meinrad Beer, MD^*,*, Tobias Seyfarth, MD^*, J.örn Sandstede, MD^*, Wilfried Landschütz, PhD, Claudia Lipke, MD^*, Herbert Köstler, PhD^*, Markus von Kienlin, PhD, Kerstin Harre, MD, Dietbert Hahn, MD^* and Stefan Neubauer, MD

^* Institut für Röntgendiagnostik, Würzburg, Germany
Physikalisches Institut V Am Hubland, Würzburg, Germany
Medizinische Klinik, Würzburg University, Würzburg, Germany
Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom

View larger version (15K): [in a new window]   Figure 1 31P-spatial localization with optimum pointspread function spectra obtained from left ventricular myocardium. (a) Healthy volunteer; (b) hypertensive heart disease; (c) aortic valve disease; (d) dilated cardiomyopathy. Concentrations for phosphocreatine (PCr) and adenosintriphosphate (ATP) and PCr/ATP ratios were as follows: (a) 9.4, 5.7, 1.65; (b) 9.5, 6.0, 1.58; (c) 5.9, 4.5, 1.31; (d) 2.8, 2.6, 1.08.

View larger version (13K): [in a new window]   Figure 2 Absolute and relative concentrations of phosphocreatine (PCr) and adenosine triphosphate (ATP) in volunteers (VOL) and in patients with hypertensive heart disease (HHD), aortic valve disease (AVD), and dilated cardiomyopathy (DCM). Individual as well as mean ± SD values are shown for each group. Analysis of variance results were as follows: PCr: VOL vs. HHD p = 0.85, VOL vs. AVD p = 0.01*, VOL vs. DCM p < 0.000001*; HHD vs. AVD p = 0.04*, HHD vs. DCM p < 0.00001*, AVD vs. DCM p < 0.03*. ATP: VOL vs. HHD p = 0.96, VOL vs. AVD p = 0.29, VOL vs. DCM p < 0.0003*; HHD vs. AVD p = 0.58, HHD vs. DCM p < 0.002*, AVD vs. DCM p = 0.052. PCr/ATP ratio: VOL vs. HHD p = 0.99, VOL vs. AVD p = 0.26, VOL vs. DCM p = 0.06, HHD vs. AVD p = 0.39, HHD vs. DCM p = 0.11, AVD vs. DCM p = 0.89.

View larger version (24K): [in a new window]   Figure 3 Correlations among functional and metabolic variables in volunteers (VOL) and in patients with hypertensive heart disease (HHD), aortic valve disease (AVD), and dilated cardiomyopathy (DCM). Correlations are shown for phosphocreatine (PCr) concentration and adenosintriphosphate (ATP) concentration, and PCr/ATP ratios with ejection fraction (EF) (left column) and end-diastolic volume (EDV) (right column). Diamonds = VOL; squares = HHD; triangles = AVD; circles = DCM.