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The prognostic value of estimated creatinine clearance alongside functional capacity in ambulatory patients with chronic congestive heart failure

Niall G. Mahon, MD^*, Eugene H. Blackstone, MD, FACC, Gary S. Francis, MD, FACC^*, Randall C. Starling, III, MD, FACC^*, James B. Young, MD, FACC^* and Michael S. Lauer, MD, FACC^*,*

^* Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Cardiothoracic Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Epidemiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Biostatistics, Cleveland Clinic Foundation, Cleveland, Ohio, USA

View larger version (17K): [in a new window]   Figure 1 Kaplan-Meier curve of survival by quartiles of baseline creatinine clearance (A) and quartiles of baseline 6-min walk distance (B).

View larger version (19K): [in a new window]   Figure 2 Hazard plot demonstrating survival according to creatinine clearance in patients with and without abnormal exercise tolerance with ejection fraction (EF), history of hospitalization, and diuretic use specified. Note that similar plots can be constructed for any specified EF, history of hospitalization, and diuretic use. WD6 = 6-min walk distance. A value of 262 m corresponded to the lowest quartile. Bold lines = probability of survival; broken lines = 95% confidence intervals.

View larger version (24K): [in a new window]   Figure 3 Hazard plot demonstrating survival according to creatinine clearance in patients with different degrees of left ventricular dysfunction, with 6-min walk distance, history of hospitalization, and diuretic use specified. Bold lines = probability of survival; broken lines = 95% confidence intervals.