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Association between the –514 ct polymorphism of the hepatic lipase gene promoter and unstable carotid plaque in patients with severe carotid artery stenosis

Elisabetta Faggin, PhD^*, Alberto Zambon, MD, PhD, Massimo Puato, MD^*, Samir S. Deeb, PhD, Sandra Bertocco, MD, Saverio Sartore, PhD, Gaetano Crepaldi, MD, Achille C. Pessina, MD, PhD^* and Paolo Pauletto, MD^*,*

^* Dipartimento di Medicina Clinica e Sperimentale, Università di Padova, Italy
Dipartimento di Scienze Mediche e Chirurgiche, Università di Padova, Italy
Department of Medical Genetics, University of Washington, Seattle, Washington, USA
Dipartimento di Scienze Biomediche e Sperimentali, Università di Padova, Italy

View larger version (116K): [in a new window]   Figure 1 Representative micrographs of carotid endarterectomy specimens form CC (A and C) and CT (B and D) genotype carriers. A prevalence of macrophages (stained with HAM56) was found in specimens obtained from the CC carriers, whereas smooth muscle cells (SMCs) (stained with SM-E7) were more numerous in specimens obtained from the CT carriers. The insets in B and C display, at high magnification, the staining of plaque areas for macrophages and SMCs, respectively. The number of cells per area unit was assessed by computerized image analysis (see Methods and ref. 10). m = tunica media; pl = atherosclerotic plaque. Bar = 80 µm. Magnification x20 Planapo objective.

View larger version (21K): [in a new window]   Figure 2 Relationship between low-density lipoprotein (LDL) density and number of macrophages in the atherosclerotic plaque. The analysis was carried out in patients from the two genotype groups who had cerebrovascular events. n/au = cells/area unit.