Plasma brain natriuretic peptide concentration: impact of age and gender
Margaret M. Redfield, MD*,*,
Richard J. Rodeheffer, MD*,
Steven J. Jacobsen, MD, PhD ,
Douglas W. Mahoney, MS ,
Kent R. Bailey, PhD and
John C. Burnett, Jr, MD*
* Division of Cardiovascular Diseases, and Sections of, Rochester, Minnesota, USA
Health Science Research and, Rochester, Minnesota, USA
Biostatistics, Mayo Clinic and Foundation, Rochester, Minnesota, USA
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Figure 1 Plasma brain natriuretic peptide (BNP) concentration as a function of age for each gender and assay system. The nomogram demonstrates the 5th, 25th, 50th, 75th, and 95th percentiles for BNP according to age.
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Figure 2 Box plot of plasma brain natriuretic peptide (BNP) concentrations (Biosite assay) according to hormone replacement therapy (HRT) status as a function of age in female (F) subjects. The box plots indicate the 5th, 25th, 50th, 75th, and 95th percentiles.
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Figure 3 Receiver operating curves defining the sensitivity and specificity of brain natriuretic peptide (BNP) (by Shionogi and Biosite assays) for the detection of systolic dysfunction (ejection fraction  40%) in each age strata of men and women. The open circle indicates the BNP value at the upper reference limit as derived from the regression fit in each age/gender/assay stratum. The open triangle indicates the BNP value with optimal sensitivity and specificity (the "optimal point") on the receiver operating characteristic (ROC) curve.
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