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J Am Coll Cardiol, 2002; 40:862-868
© 2002 by the American College of Cardiology Foundation
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Deoxyribonucleic acid damage in human lymphocytes after percutaneous transluminal coronary angioplasty

Maria Grazia Andreassi, BSc*,*, Nicoletta Botto, BSc*, Antonio Rizza, MD*, Maria Giovanna Colombo, BSc*, Cataldo Palmieri, MD*, Sergio Berti, MD*, Samantha Manfredi, BSc*, Serena Masetti, BSc*, Aldo Clerico, MD* and Andrea Biagini, MD*

* Laboratory of Cellular Biology, CNR Institute of Clinical Physiology, G. Pasquinucci Hospital, Massa, Italy




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  		Figure 1 An example of micronucleated binucleated cells with two micronuclei (A) and cell migration patterns produced by the comet assay (B).

 


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  		Figure 2 Deoxyribonucleic acid (DNA) damage, as demonstrated by single strand breaks (SSBs), formamidopyrimidine glycosylase (FPG) sites, and endonuclease III (E III) sites, in the lymphocytes of patients classified into three study groups, represented by the mean percent DNA in the tail for 50 comets from each patient.

 


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  		Figure 3 Frequency of micronucleated binucleated cells in patients undergoing percutaneous transluminal coronary angiography (group I) and coronary angiography (group II). Open bars = before procedure; solid bars = after procedure.

 


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  		Figure 4 Relationship between micronucleated binucleated (MNBN) cell increase after percutaneous transluminal coronary angiography and total inflation time. y = 1.123 + 0.072x; r = 0.549, p = 0.002.

 


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  		Figure 5 Deoxyribonucleic acid (DNA)-single strand breaks (SSBs) in patients undergoing percutaneous transluminal coronary angiography (group I) and coronary angiography (group II). Open bars = before procedure; solid bars = after procedure.

 




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