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Production of 8-epi prostaglandin F₂ in human platelets during administration of organic nitrates

^* Department of Therapeutics and Pharmacology, Queen’s University Belfast, Belfast, Ireland

View larger version (12K): [in a new window]   Figure 1 Plasma ascorbate concentrations at baseline and after 72 h of nonintermittent transdermal nitroglycerin (NTG) (10 mg/24 h) with co-administration of placebo (NTG/placebo) or ascorbic acid (NTG/ascorbate). Data are presented as the mean value (95% CI). *p < 0.01.

View larger version (16K): [in a new window]   Figure 2 Platelet membrane esterified 8-epi prostaglandin2 (isoprostane) content at baseline and after 72 h of nonintermittent transdermal nitroglycerin (NTG) (10 mg/24 h) with co-administration of placebo (NTG/placebo) or ascorbic acid (NTG/ascorbate). Data are presented as the mean value (95% CI). *p < 0.05.

View larger version (13K): [in a new window]   Figure 3 Change in platelet membrane esterified 8-epi prostaglandin F2 (isoprostane) content after 72 h of nonintermittent transdermal nitroglycerin (NTG) (10 mg/24 h) with co-administration of placebo (NTG/placebo) or ascorbic acid (NTG/ascorbate). Data are presented as the mean value (95% CI). *p < 0.05.