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Acute effects of vasoactive drug treatment on brachial artery reactivity

^* Evans Department of Medicine, Cardiology Section and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA

View larger version (15K): [in a new window]   Figure 1 The effect of a single oral dose of vasoactive medication on systolic blood pressure (SBP) (mm Hg) and absolute percent change in brachial artery flow-mediated (FMD) and nitroglycerin-mediated dilation (NMD) in normal subjects. Examinations were performed at baseline and 3 h after treatment with either placebo, felodipine (5 mg), metoprolol (50 mg), or enalapril (10 mg). *All three drugs lowered blood pressure significantly (p < 0.05) but had no effect on FMD or NMD. Open bar = change in SBP (mm Hg); solid bar = change in FMD (%); hatched bar = change in NMD (%).