contribution of major cardiovascular risk factors to familial premature coronary artery disease
The GENECARD project
Vincent Jomini, MD*,
S.éverine Oppliger-Pasquali, MD*,
Vincent Wietlisbach, BA ,
Nicolas Rodondi, MD ,
Valérie Jotterand, MD*,
Fred Paccaud, MD ,
Roger Darioli, MD ,
Pascal Nicod, MD* and
Vincent Mooser, MD*,*
* Department of Medicine, CHUV University Hospital, Lausanne, Switzerland
Institute for Social and Preventive Medicine, CHUV University Hospital, Lausanne, Switzerland,
University Medical Policlinic, Lausanne, Switzerland

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Figure 1 Strategy used to recruit premature coronary artery disease (P-CAD)affected sibling pairs and to identify patients with sporadic P-CAD. A total of 110 patients with familial P-CAD were originally identified, but 7 refused to enter the study, so that 103 probands with familial P-CAD and 110 affected siblings were eventually recruited.
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Figure 3 The prevalence of risk factors in the general population (open diamonds), in patients with sporadic premature coronary artery disease (P-CAD) (solid triangles) and in patients with familial P-CAD (solid circles), according to age tertiles. Groups and risk factors were defined as described in the legend to Figure 2. *p < 0.05 familial versus sporadic P-CAD; ***p < 0.001.
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Figure 4 Aggregation of cardiovascular risk factors at the time of the event in six sibships with at least three siblings affected with premature coronary artery disease (P-CAD). Males are represented by squares and females by circles. The numbers beneath the symbols refer to the age when the diagnosis of P-CAD was made, whereas the age for the parents refers to the age at death (numbers in parentheses) or at the time that their P-CADaffected siblings were recruited (age at death of the father for family no. 39 was unknown). Solid upper left corner = hypertension; solid lower left corner = smoking; solid upper right corner = hypercholesterolemia; and solid lower right corner = obesity and/or diabetes, as defined in the legend to Figure 2. Arrows indicate probands. Plasma cholesterol levels were missing for siblings 1 and 3 from family no. 53, sibling 1 from family no. 80 and sibling 1 from family no. 96, and the diagnosis of hypercholesterolemia was based on values obtained when these individuals were recruited. The father in family no. 80 died of P-CAD at age 49 years.
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